What You Need To Know About Trikafta
Trikafta is a prescription medication that has transformed the way doctors treat cystic fibrosis (CF) — a genetic disease that causes thick, sticky mucus to build up in the lungs and other organs. Approved by the U.S. FDA in 2019, Trikafta offers new hope to thousands of people living with CF, including many who previously had no effective treatment options.
How Trikafta Works
Cystic fibrosis is caused by mutations in the CFTR gene, which makes a protein responsible for controlling the flow of salt and water in and out of cells. When this protein doesn’t work correctly, mucus builds up, leading to lung infections and digestive problems.
Trikafta combines three medicines — elexacaftor, tezacaftor, and ivacaftor — that work together to help the defective CFTR protein function more normally.
- Elexacaftor and tezacaftor help the CFTR protein reach the cell surface.
- Ivacaftor improves how the protein works once it’s there.
This triple combination helps improve lung function, reduce flare-ups, and enhance overall quality of life.
Who Can Take Trikafta?
Trikafta is approved for people with cystic fibrosis who have at least one F508del mutation in the CFTR gene — the most common cause of CF. It can be prescribed to patients 6 years and older, depending on their health and genetic profile.
Genetic testing is required before starting treatment to confirm eligibility.
How It’s Taken
Trikafta is taken by mouth, usually as two tablets in the morning and one tablet in the evening, with fatty food to help absorption. It’s a daily therapy designed for long-term use.
Common Side Effects
Most side effects are mild and manageable. The most common include:
- Headache
- Diarrhea
- Stomach pain
- Increased liver enzyme levels
- Rash or dizziness
Doctors may perform regular blood tests to monitor liver function while on Trikafta.
Benefits of Trikafta
Clinical studies have shown that Trikafta can:
- Improve lung function (FEV1) significantly
- Reduce pulmonary exacerbations (lung flare-ups)
- Increase weight and energy levels
- Enhance overall quality of life
For many people with CF, Trikafta feels like a life-changing treatment — improving breathing, stamina, and daily comfort.
Final Thoughts
Trikafta has redefined what’s possible for people with cystic fibrosis. By targeting the root cause of the disease rather than just its symptoms, it offers a brighter, healthier future for thousands of patients and families.
If you or your child have CF, talk to your care team about genetic testing and whether Trikafta could be the right treatment option.